The Meeting will be preceded by the Convention, “Physical Exercise in Health Promotion: Integrating Muscle Contraction with Nutrition” (in Italian) organized in collaboration with the Italian National Olympic Committee (CONI); 4 September 2024, 9:30 AM, Hotel Cenacolo.

• Wednesday
  4 September THU
  4 Sep
• Thursday
  5 September THU
  5 Sep
• Friday
  6 September FRI
  6 Sep
• Saturday
  7 September SAT
  7 Sep
• List of
  Posters List of
  Posters List
  of
  Post

• Convegno (Assisi, Hotel Cenacolo) L’ESERCIZIO FISICO COME PREVENZIONE Dalla contrazione muscolare alla nutrizione Moderatori: Guglielmo Sorci (Università di Perugia; Direttore IIM) Anna Villarini (Università di Perugia)

  9:30	Saluti delle Autorità
  9:50	Francesca Riuzzi (Università di Perugia; IIM) Evoluzione e proprietà del muscolo scheletrico
  10:10	Antonio Musarò (Università Sapienza Roma; IIM) Il muscolo come organo endocrino. Le miochine
  10:30	Massimo Raffaele Mannarino (Università di Perugia) Effetti benefici dell’esercizio fisico. Esercizio fisico come poli-pillola
  10:50	Raffaella Spada (Istituto di Medicina e Scienza dello Sport - CONI) Aspetti nutrizionali legati all’esercizio fisico
  11:10	Roberto Cammarelle (ex pugile, campione olimpico e campione del mondo) La mia esperienza da campione
  11:40	Discussione generale
  12:00	Conclusioni
  Diretta streaming su questo sito.

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  15:00-15:10	Welcome and opening of the IIM meeting
  15:10-15:50	Lecture 1 Chair: Giacomo Rubini (Young IIM Committee) Leonardo F. Ferreira (Duke University, Durham, NC, USA) Molecular and biophysical basis of skeletal muscle dysfunction in heart failure
  15:50-17:00	Session 1: Muscle function and weakness Chairs: Dario Coletti, Sara Roccabianca Stefano Perni (Siena, Italy) EC-coupling and beyond. Dissecting the molecular interactions in the SR/ER-PM junctions of muscle and nerve Charlotte Gineste (SFM; Illkirch-Graffenstaden, France) Testing tamoxifen as a potential therapeutic approach in Stim1-related TAM/STRMK murine model Federica Fiore* (Siena, Italy) Evaluating miR-486 overexpression as a potential therapeutic approach in mouse models of RyR1-related myopathies Jacqueline Ji* (Illkirch-Graffenstaden, France) Gene replacement to cure BIN1 centronuclear myopathy
  17:00-17:30	Coffee break
  17:30-18:55	Session 2/a: Muscle diseases and regenerative medicine Chairs: France Pietri-Rouxel, Beatrice Biferali Lorenzo Giordani (Paris, France) Multimodal Single Cell spatial profiling of Duchenne Muscular Dystrophy Caterina Boccia* (Rome, Italy) Targeting IL-6 signalling to attenuate dystrophic muscle degeneration Sonia Albini (Evry, France) Disease exacerbation in MYOrganoids derived from Duchenne Muscular Dystrophy iPSC reveals limitations of microdystrophin therapeutic efficacy Laura Lociuro* (Milan, Italy) Enhancing micro-dystrophin gene therapy: the role of SRT2104, a new Sirtuin1-activating compound, for the treatment of Duchenne Muscular Dystrophy Ilaria Zito (Parent Project; Rome, Italy) The role of patients’ associations in IHI European multi-partner projects
  19:30	Dinner - Aperitivo Umbro and (only for participants registered for the Advanced Myology Update course) Roundtable 1: "How to choose a lab for a Post-Doc experience" with M. Rudnicki and J. von Maltzahn Roundtable 2 "Approaches to optimize the Post-Doc experience" with L. Ferreira and D. Guttridge

  *Young Investigator. Eligible for Best Talk awards.

• 9:00-10:10	Session 2/b: Muscle diseases and regenerative medicine Chairs: Cesare Gargioli, Mariam Zouhair Riccardo Gamberale* (Monza, Italy) Characterization of the infiltrating polarized macrophages during the onset of heterotopic ossification in a mouse model of Fibrodysplasia Ossificans Progressiva Cassandra Margotta* (Milan, Italy) Enhancing skeletal muscle regeneration in ALS via intramuscular allosteric activation of the P2X7 receptor Rodrigo D’Amico* (Rome, Italy) Consequences of CNBP reduced expression in DM2 pathogenesis Alexis Boulinguiez (SFM; Egham, United Kingdom) Different outcomes of endurance and resistance exercise in skeletal muscles of Oculopharyngeal muscular dystrophy
  10:10-10:35	Coffee break
  10:35-11:15	Lecture 2 Chair: Pier Lorenzo Puri Michael Rudnicki (Ottawa Hospital Research Institute, Ottawa, Canada) Molecular regulation of muscle stem cell function
  11:15-12:25	Session 3: Muscle stem cells and stem cell niche Chairs: Chiara Sassoli, Federica Esposito Andrea Münsterberg (Norwich, United Kingdom) Muscle stem cell function is impaired in absence of Talpid3 - a gene required for primary cilia formation Cristina Parisi* (Rome, Italy) Fibro-Adipogenic Progenitors (FAPs) facilitate skeletal muscle reinnervation via retinoic acid release Stefano Cagnin (Padua, Italy) Non-coding RNAs to Treat Skeletal Muscle Atrophy Nikki Wanders* (Maastricht, The Netherlands) Experimental autoimmune encephalomyelitis induced muscle loss in mice triggers engraftment of systemically administered mesoangioblasts
  12:25-12:40	Technical talk (by Prodotti Gianni/Abcam) Danilo Lemos Tackling reproducibility crisis with recombinant technology
  12:40-12:50	Poster blitz 1 (ODD NUMBERS; selection)
  13:00	Lunch
  14:30-16:00	Poster Session 1 (ODD NUMBERS)
  16:00	Bus departure to Assisi: guided tour of the Basilica of Saint Francis or the "Rocca Maggiore" Fortress (free time after the visits)
  19:00	Bus departure to the “Cantico di San Francesco” restaurant

  *Young Investigator. Eligible for Best Talk awards.

• 9:00-9:40	Lecture 3 Chair: Maurilio Sampaolesi Julia von Maltzahn (Brandenburg University of Technology, Cottbus-Senftenberg, Germany) Muscle stem cells in age and disease
  9:40-10:40	Session 4: Muscle aging Chairs: Libero Vitiello, Katja Hönzke Giacomo Bincoletto* (Padua, Italy) Premature aging of skeletal muscle of Kennedy disease mouse models Susanna Molinari (Modena, Italy) Nanoparticle-mediated delivery to skeletal muscle cells of N-palmitoylethanolamide (PEA), an endocannabinoid-like molecule with anti-inflammatory properties Clara Sciorati (Milan, Italy) Sarcopenic obesity in the elderly: a dysfunctional crosstalk between tissues?
  10:40-11:10	Coffee break
  11:10-12:20	Session 5: Genetic and epigenetic regulation in muscle pathologies Chairs: Vanina Romanello, Alex Pezzotta Paul Kemp (London, United Kingdom) The H19/Let-7/myc axis regulates muscle inflammatory responses Emanuele Mocciaro (Milan, Italy) Pre-clinical development of a drug inhibiting the chromatin remodeling protein WDR5 in FSHD muscular dystrophy Alexis Osseni (SFM; Lyon, France) Inhibition of HDAC6 improves muscle integrity in Duchenne Muscular Dystrophy mouse model Ashley (Ju-Wei) Wang* (Leuven, Belgium) Investigating the potential of MICAL2 modulation for impeding rhabdomyosarcoma cancer progression
  12:20-12:30	Poster blitz 2 (EVEN NUMBERS; selection)
  13:00	Lunch
  14:30-16:00	Poster Session 2 (EVEN NUMBERS)
  16:00-16:40	Lecture 4 Chair: Fabio Penna Denis C. Guttridge (Medical University of South Carolina, Charleston, SC, USA) Regulation of the inflammatory muscle microenvironment in cancer cachexia
  16:40-17:00	Coffee break
  17:00-18:45	Session 6: Muscle wasting and cachexia Chairs: Andy Judge, Sara Chiappalupi Gabriele Guarnaccia* (San Diego, CA, USA) Serum amyloid protein A1 (SAA1) impairs myogenesis and myotube size in pancreatic cancer cachexia Martina Biglietto* (Rome, Italy) Engineered exosomes as a therapeutic tool to counteract muscle degeneration Giacomo Rubini* (Turin, Italy) Immunomodulation via interleukin-4 improves energy metabolism in C26 tumor-bearing mice Martina Paiella* (Novara, Italy) Western diet worsens cancer-induced muscle wasting which is restrained by Vaccinium macrocarpon extract Andy Judge (Gainesville, FL, USA) Muscle directed nutrition for cancer cachexia Andrea Ghiroldi (Cinisello Balsamo, Italy) Unraveling the therapeutic potential of givinostat in muscle atrophy induction
  18:45-19:30	IIM General meeting
  20:00	Social Dinner - Awards and prizes
  22:00	Dance party

  *Young Investigator. Eligible for Best Talk awards.

• High Training Course in ADVANCED MYOLOGY UPDATE 2024
  10:00	Bus departure to Palazzo Bernabei
  10:30	J. von Maltzahn Driving rhabdomyosarcoma into myogenic differentiation
  11:00	L. Ferreira Assessment of muscle function in rodents: old approaches, modern applications
  11:30	M. Rudnicki Developing innovative regenerative therapies for neuromuscular diseases
  12:00	D. Guttridge Identifying limitations in mouse models of cancer cachexia
  12:30	Light lunch

• Posters always on display during the meeting

  Discussions: ODD numbers – Thursday, 5 September (14:30-16:00)
  EVEN numbers – Friday, 6 September (14:30-16:00)

  P.1  Valentina Guardascione** (Siena, Italy)
  Evaluation of miR-486 expression levels in mice skeletal muscle under different metabolic conditions
  
  P.2  Sara Roccabianca** (Siena, Italy)
  Changes in CLIMP63 expression alter the organization of the microtubule network of mouse skeletal muscle fibers
  
  P.3  Lucrezia Puccini** (Siena, Italy)
  Gene expression analysis in skeletal muscles of mice carrying a deletion in a muscle-specific stretch/super enhancer region inside the ANK1 locus
  
  P.4  Paul Kemp (London, United Kingdom)
  Regulation of individual sensitivity to inflammation by myc contributes to muscle loss in COPD
  
  P.5  Marco Simula** (Rome, Italy)
  Long noncoding RNAs at the interface between muscles and nerves
  
  P.6  Maxime Gelin** (Paris, France)
  Exploring the role of GDF5 in neuromuscular system during growth and physical activity
  
  P.7  Margaux Van Puyvelde** (Leuven, Belgium)
  A meta-analysis of state-of-the-art in vitro generated skeletal muscle  
  
  P.8  Muhammad Dawood Amjad** (Chieti, Italy)
  Complex Magnetic Fields (CMFs): harnessing electromagnetic symphony for muscle regeneration
  
  P.9  Alessandro Arcari** (Milan, Italy)
  Lights and shadows of neuropsychiatric drugs on skeletal muscle in Duchenne muscular dystrophy
  
  P.10  Pietro Chiolerio** (Padua, Italy)
  Exploring the role of extracellular matrix in neuromesodermal differentiation of human induced pluripotent stem cells
  
  P.11  Aly Bourguiba Villeneuve** (Paris, France)
  GDF5 therapeutic potential on neuromuscular junction defects
  
  P.12  Sabrina D'Amore** (Chieti, Italy)
  Cell adhesion and migration: an important determinant of GTP-dependent myogenesis
  
  P.13  Beatrice Biferali** (Milan, Italy)
  Understanding and treating inflammation in FSHD muscular dystrophy
  
  P.14  Francesca De Paolis** (Rome, Italy)
  Human mytendineous junction 3D in vitro modeling 
  
  P.15  Giorgia Cavioli** (Rome, Italy)
  HDAC4 mediates the crosstalk between skeletal muscle fibers and fibro-adipogenic progenitors in Duchenne Muscular Dystrophy
  
  P.16  Rebecca Deodati** (Rome, Italy)
  Skeletal Muscle Tissue Engineering a promising technology in the field of food
  
  P.18  Federica Esposito** (Milan, Italy)
  Exploring the role of HMGB1 in nuclei dynamics during myogenesis
  
  P.19  Fabiana Fanelli** (Urbino, Italy)
  Effect of tunicamycin treatment on IGF1R production and IGF1R signaling pathway activation in C2C12
  
  P.20  Rachele Garella (Florence, Italy)
  New tools to evaluate satellite cell activation after eccentric contraction-induced damage at the muscle-tendon junction in mice: the light sheet microscopy
  
  P.21  Serena Germani** (Milan, Italy)
  CHOP/ERO1A pathway of unfolded protein response (UPR) in RYR1 and SEPN1-related myopathies
  
  P.22  Martina Parigi** (Florence, Italy)
  Red photobiomodulation promotes skeletal myoblast differentiation and counteracts anti-myogenic effects of TGF-β1: new perspective for muscle regenerative medicine
  
  P.23  Alex Pezzotta** (Milan, Italy)
  Improving the effects of HDAC8 inhibition by combining the activation of SIRT1 in a zebrafish model of Duchenne muscular dystrophy
  
  P.24  Elena Ruggieri** (Milan, Italy)
  High Mobility Group Box 1 recycling orchestrates regeneration in skeletal muscle
  
  P.26  Cristina Purcaro** (Chieti, Italy)
  Environmental pollutants impact on adult and pluripotent-derived myogenic progenitors
  
  P.27  Ilaria Versari** (Bologna, Italy)
  Nuclear Phospholipase C delta 4 is a crucial player in modulation of rhabdomyosarcoma cells proliferation
  
  P.28  Fabio Ferrini (Urbino, Italy)
  Hyaluronan improves the C2C12 murine myoblast proliferation and myogenic differentiation under oxidative and inflammatory conditions
  
  P.29  Francesco Millozzi** (Rome, Italy)
  Aptamer-conjugated gold nanoparticles enable selective oligonucleotide delivery into muscle stem cells to promote regeneration of dystrophic muscles
  
  P.30  Alessandro Antonioli** (Novara, Italy)
  Ketogenic diet mitigates liver damage but not muscle atrophy in western diet-induced obesity
  
  P.31  Paul Kemp (London, United Kingdom)
  AntagomiR inhibition of miR-424(322) increases muscle fibre diameter in old mice and in response to respiratory viral infection
  
  P.32  Bianca Bartoloni** (Florence, Italy)
  An autocrine loop of lactate sustains cancer cachexia in skeletal muscle
  
  P.33  Frida Karakashi** (Milan, Italy)
  Menin is a novel therapeutic target for FSHD muscular dystrophy
  
  P.34  Lorenza Bodo** (Turin, Italy)
  The role of Pde4d transcript variants in restraining cAMP signaling in cancer cachexia
  
  P.35  Martina Lupoli** (Rome, Italy)
  The role of Protein-Kinase C Theta in muscle-nerve communication: the case of Amyotrophic Lateral Sclerosis and Myasthenia Gravis
  
  P.36  Karolina Majchrzak** (Senftenberg, Germany)
  Role of Sbno2 in myogenic differentiation under cachectic conditions
  
  P.37  Mariam Zouhair** (Rome, Italy)
  3D skeletal muscle construct for in vitro recapitulation of Duchenne Muscular Dystrophy Progression
  
  P.38  Michele Mannelli** (Florence, Italy)
  Auranofin, a potential drug to counteract cancer cachexia in skeletal muscle
  
  P.39  Giovanni Delli Carpini** (Rome, Italy)
  In vivo restoration of dystrophin expression in mdx mice using antisense oligonucleotides (ASOs) conjugated to gold nanoparticles
  
  P.40  Mark Griffiths (London, United Kingdom)
  Metabolomic markers of mitochondrial dysfunction predict recovery of muscle mass in a human model of acute muscle wasting
  
  P.41  Katja Hönzke (Senftenberg, Germany)
  Investigation of the role of different IQgap proteins in myogenesis
  
  P.42  Tommaso Raiteri** (Perugia, Italy)
  Dietary and endogenous advanced glycation end-products (AGEs) induce muscle wasting in vitro which could be counteracted by Vaccinium macrocarpon extract
  
  P.43  Libero Vitiello (Padua, Italy)
  Targeting monoamine oxidase B (MAOB) in dystrophic mdx hearts dampens inflammation and fibrosis
  
  P.44  Laura Salvadori (Novara, Italy)
  Vaccinium macrocarpon extract restrains muscle wasting induced by Western diet-derived AGEs
  
  P.45  Giorgia Maria Renna** (Milan, Italy)
  Molecular characterization of ER stress mediators in the pathogenesis of SEPN1 and RYR1-related myopathies
  
  P.46  Sara Chiappalupi (Perugia, Italy)
  Proteomic analysis suggests novel mechanisms involved in the protection against cancer-induced muscle wasting in mice lacking RAGE at myofiber level
  
  

  **Young Investigator. Eligible for Best Poster Blitz and Best Poster awards.